In this study, we proposed a U-shaped optical fiber probe fabricated using a flame heating\nmethod. The probe was packaged in glass tube to reduce human factors during experimental testing\nof the probe as a glucose sensor. The U-shaped fiber probe was found to have high sensitivity in\ndetecting the very small molecule. When the sensor was dipped in solutions with different refractive\nindexes, its wavelength or transmission loss changed. We used electrostatic self-assembly to bond\ngold nanoparticles and glucose oxidase (GOD) onto the sensor�s surface. The results over five cycles of\nthe experiment showed that, as the glucose concentration increased, the refractive index of the sensor\ndecreased and its spectrum wavelength shifted. The best wavelength sensitivity was 2.899 nm/%,\nand the linearity was 0.9771. The best transmission loss sensitivity was 5.101 dB/%, and the linearity\nwas 0.9734. Therefore, the proposed U-shaped optical fiber probe with gold nanoparticles and GOD\nhas good potential for use as a blood sugar sensor in the future.
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